After the passing of her mother, a young woman in a wheelchair since birth, is forced to deal with her sister, brother-in-law, niece and their nanny as they say their goodbyes to mother. When people start turning up dead, Nica discovers the culprit might be a strange doll she received a few days earlier.

Chucky and Tiffany are resurrected by their innocent son, Glen, and hit Hollywood, where a movie depicting the killer dolls’ murder spree is underway.

Confined to an asylum for the criminally insane for the past four years, Nica Pierce is erroneously convinced that she, not Chucky, murdered her entire family. But when her psychiatrist introduces a new therapeutic “tool” to facilitate his patients’ group sessions — an all-too-familiar “Good Guy” doll with an innocently smiling face — a string of grisly deaths begins to plague the asylum, and Nica starts to wonder if maybe she isn’t crazy after all. Meanwhile, Andy Barclay, Chucky’s now all-grown-up nemesis from the first three Child’s Plays, races to Nica’s aid. But to save her he’ll have to get past Tiffany, Chucky’s long-ago bride, who will do anything, no matter how deadly or depraved, to help her beloved evil devilish doll.