A standup comic discovers that his wife is unfaithful, leading him to reevaluate his life amidst the New York City comedy scene.

Rebellious Mickey and good-natured Gus navigate the thrills and agonies of modern relationships.

The assorted humiliations, disasters and rare triumphs of four very different twenty-something girls: Hannah, an aspiring writer; Marnie, an art gallery assistant and cousins Jessa and Shoshanna.