Two bounty hunters are in pursuit of “El Indio,” one of the most wanted fugitives in the western territories, and his gang.

The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.

Jack Beauregard, one of the greatest gunman of the Old West, only wants to retire in peace and move to Europe. But a young gunfighter, known as “Nobody”, who idolizes Beauregard, wants him to go out in glory. So he arranges for Jack to face the 150-man gang known as The Wild Bunch and earn his place in history.

Lee Van Cleef stars as Talby, a sadistic gunfighter who rides into town and takes on a young outcast as his apprentice.