On a remote former submarine refueling facility called Aquatica, a team of scientists are searching for a cure for Alzheimer’s disease. Dr. Susan McAlester genetically engineers three Mako sharks, intending to increase their brain capacity so that they can harvest the tissue as a cure for Alzheimer’s. Unfortunately, the increased brain capacity also makes the sharks smarter, faster, and more dangerous. Aquatica’s financial backers are skeptical and nervous about the tests, and send a corporate executive to visit the facility.

Terry Noonan returns home to New York’s Hells Kitchen after a ten year absence. He soon hooks up with childhood pal Jackie who is involved in the Irish mob run by his brother Frankie. Terry also rekindles an old flame with Jackie’s sister Kathleen. Soon, however, Terry is torn between his loyalty to his friends and his loyalties to others.

Renegade FBI agent Art Jeffries protects a nine-year-old autistic boy who has cracked the government’s new “unbreakable” code.