Naive American engineer Howard Graham (Joseph Cotton) is taken by a fellow employee to an Istanbul nightclub, where he becomes attracted to dancer Josette Martel (Dolores del Rio). An attempt to murder him results in the death of an unfortunate magician instead.

Frank Johnson, sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank’s wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.