After several coeds are murdered at a college, a professor (Fabio Testi) who is involved with a student becomes a suspect, along with several other male and female teachers.

Renowned gunman Richard Martin is traveling on a train, held up by Billy Kane, a former student of Martin’s. Kane spares Martin, but only after shooting his hands. Years later, Martin meets an escaped convict, wrongly convicted for the train robbery. Martin trains his new student and both men seek out Billy Kane.