In the 1970s, a British sound technician is brought to Italy to work on the sound effects for a gruesome horror film. His nightmarish task slowly takes over his psyche, driving him to confront his own past.

In this chilling sequel to 28 Days Later, the inhabitants of the British Isles appear to have lost their battle against the onslaught of disease, as the deadly rage virus has killed every citizen there. Six months later, a group of Americans dare to set foot on the isles, convinced the danger has come and gone. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.