The disappearance of a young Cree woman in Toronto traumatizes her Northern Ontario family, and sends her twin sister on a journey south to find her.

Various citizens of Toronto anxiously await the end of the world, which is occurring at the stroke of midnight on New Year’s Day. While widower Patrick Wheeler braces for his fate, he meets Sandra, the wife of a businessman who is intent on committing suicide. Meanwhile, Patrick’s friend Craig decides to have as much sex as he can while there is still time.

A small fishing village must procure a local doctor to secure a lucrative business contract. When unlikely candidate and big city doctor Paul Lewis lands in their lap for a trial residence, the townsfolk rally together to charm him into staying. As the doctor’s time in the village winds to a close, acting mayor Murray French has no choice but to pull out all the stops and begin The Grand Seduction.