When young women begin to disappear across a small town, a police officer and a street-smart social worker follow clues to a remote pig farm and discover the local butcher has been bringing his work home.

Doctor Channard is sent a new patient, a girl warning of the terrible creatures that have destroyed her family, Cenobites who offer the most intense sensations of pleasure and pain. But Channard has been searching for the doorway to Hell for years, and Kirsty must follow him to save her father and witness the power struggles among the newly damned.