90210 revolves around several students at the fictional West Beverly Hills High School, including new Beverly Hills residents Annie Wilson and Dixon Wilson. Their father, Harry Wilson, has returned from Kansas to his Beverly Hills childhood home with his family to care for his mother, former television and theater actress Tabitha Wilson, who has a drinking problem and clashes with his wife Debbie Wilson. Annie and Dixon struggle to adjust to their new lives while making friends and yet adhering to their parents’ wishes.

The stories of the men and women who work the overnight shift at San Antonio Memorial Hospital. They are an irreverent and special breed, particularly adrenaline junkie T.C. Callahan.