While driving, the pregnant horror-movie actress Kyôko Harase and her fiancé are in a car crash caused by the Toshio’s friend. Kyôko loses her baby and her fiancé winds up in a coma. Kyôko was cursed together with a television crew when they shot a show in the haunted house where Kayako was brutally murdered by her husband years ago.

In Tokyo, a young woman is exposed to the same mysterious curse that afflicted her sister. The supernatural force, which fills a person with rage before spreading to its next victim, brings together a group of previously unrelated people who attempt to unlock its secret to save their lives.