“Six Flying Dragons” is a Period drama depicts the ambitions and success stories of 6 people around Prince Lee Bang Won. This drama also depicts the ideological and political conflict between Prince Lee Bang Won and Jung Do Jeon who is the man instrumental in helping King Taejo to establish the fledgling Joseon nation. Jung Do Jeon wants a country ruled by ministers, while Lee Bang Won wants absolute power. Prince Lee Bang Won later become King TaeJong who was the third king in the Joseon Dynasty. He helped his father King Taejo to establish the Joseon Dynasty.

Lee Young-O is an excellent neurosurgeon with zero sympathy. One day, he becomes involved in bizarre patient deaths. He also falls in love and recovers his humanity.