The story of sisters Lillian and Grace who open an orphanage in the 1916 Western town of Brookfield. Caught between the traditions of cattle ranchers and the ambitions of a growing town, they strive to find romance and happiness while overcoming the challenges of helping the children in their care.

Follow five young nurses working on the frontlines of a busy hospital in downtown Toronto, dedicating their lives to helping others, while struggling to help themselves.