In a Bronx dispatch the aspirations and misdeeds of cab drivers, call girls and low level thugs collide in one wild night.

Once a known counterculture figure, June E. Leigh now lives in self-imposed exile in her South Bronx apartment during the incendiary ’77 Summer of Sam. When an unseen tormentor begins exploiting June’s weaknesses, her insular universe begins to unravel.

Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.

Immersed in the underbelly of Brooklyn, NY, a bargain between two gangsters gets cuckoo when one of the gangsters hires a voodoo worker to overthrow his rival.