Carl Fredricksen spent his entire life dreaming of exploring the globe and experiencing life to its fullest. But at age 78, life seems to have passed him by, until a twist of fate (and a persistent 8-year old Wilderness Explorer named Russell) gives him a new lease on life.

Some time after the Mousekewitz’s have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan.