Most Evil is an American forensics television program on Investigation Discovery presented by forensic psychiatrist Michael Stone of Columbia University. On the show, Stone rates murderers on a scale of evil that Stone himself has developed. The show features profiles on various murderers, serial killers, mass murderers and psychopaths.

In October 2009, the filmmakers went into an abandoned psychiatric hospital to explore the ‘haunted’ institution, famous for its radical treatment of patients with mental illness. Electroshock, insulin therapy, and lobotomies were commonplace. Once inside, the filmmakers quickly discovered that they were not alone.