Eliseo is ugly, lame and single. He hasn’t met the woman of his life and has never known love. Nati is ugly, missing a breast and separated. She found the man of her life but, even so, has never experienced true love. Eliseo thinks that the worst of his life is still to come. Nati thinks that the best of her life is still to come. The death of Eliseo’s mother reunites them twenty years on in a last chance to find happiness and love. But what happens when the woman of your life is married to your brother

In 1901, Marcela Gracia Ibeas took on the identity of Mario Sánchez to marry her lover of fifteen years, Elisa Sanchez Loriga.

Isabel is an actress recent in her 40 years old, unable to get new roles for movies or theaters, since then directors looking for younger women. She is married with the neurotic Ángel, a screenwriter who is working in his next cinema project with Susana, his producer and ex wife. After Isabel, Ángel, Susana and Carlos, Isabel’s first husband, send away to them respective child to a school excursion, Isabel accepts to organize in her house a business dinner for Diego, an important Argentinian actor to negotiate his participation in the movie. During the dinner Carlos appears suddenly with a young girl called Álex, announcing their next wedding and moving to Brasil. But when a little time later Carlos dies unexpectedly, Ángel and Susana suspects of the guilty of Isabel, starting a series of events more maddened each time, along a long night where surprises seems not having end…