Former champion boxer Orlando Leone (Carmen) is “The Preacher” at an inner-city youth center. Wanting to give something back to the community, he bought a large building for a church youth center. But the cash ran out before he could finish fixing it up and now, the mortgage company is about to foreclose. With his bills mounting he agrees to one last fight.

The residents of a rural mining town discover that an unfortunate chemical spill has caused hundreds of little spiders to mutate overnight to the size of SUVs. It’s then up to mining engineer Chris McCormack and Sheriff Sam Parker to mobilize an eclectic group of townspeople, including the Sheriff’s young son, Mike, her daughter, Ashley, and paranoid radio announcer Harlan, into battle against the bloodthirsty eight-legged beasts.