American astronaut Emma Green must leave her husband and teenage daughter behind to command an international space crew embarking upon a treacherous mission. A series about hope, humanity and how we need one another if we are to achieve impossible things.

Karen Best has a big life. She’s a big girl with a big personality and a big love of Chardonnay, which occasionally, causes her to make some big mistakes with men. But the biggest thing about Karen is her big heart, a heart she uses to excel at her job as a counselor at a group home for young adults with Down syndrome located in an old brownstone in New York City.