Robert Neville, a doctor, due to an experimental vaccine, is the only survivor of an apocalyptic war waged with biological weapons. The plague caused by the war has killed everyone else except for a few hundred deformed, nocturnal people calling themselves “The Family”. The plague has caused them to become sensitive to light, as well as homicidally psychotic.

Dirty Harry Callahan returns again, this time saddled with a rookie female partner. Together, they must stop a terrorist group consisting of angry Vietnam veterans.