Travelling businessman, David Mann, angers the driver of a rusty tanker whilst crossing the Californian desert. A simple trip turns deadly as Mann struggles to stay on the road while the tanker plays cat and mouse with his life.

David, a college student, is looking for a job. He is hired by Dr. Stoner as a lab assistant for his research and experiments on snakes. David also begins to fall for Stoner’s young daughter, Kristina. However, the good doctor has secretly brewed up a serum that can transform any man into a King Cobra snake-and he plans to use it on David.