Successful surgeon Tomas leaves Prague for an operation, meets a young photographer named Tereza, and brings her back with him. Tereza is surprised to learn that Tomas is already having an affair with the bohemian Sabina, but when the Soviet invasion occurs, all three flee to Switzerland. Sabina begins an affair, Tom continues womanizing, and Tereza, disgusted, returns to Czechoslovakia. Realizing his mistake, Tomas decides to chase after her.

While traveling in Paris, author Henry Miller and his wife, June, meet Anais Nin, and sexual sparks fly as Nin starts an affair with the openly bisexual June. When June is forced to return to the U.S., she gives Nin her blessing to sleep with her husband. Then, when June returns to France, an unexpected, and sometimes contentious, threesome forms.