When the pets accidentally get separated from their vacationing owners, Chance, Shadow, and Sassy navigate the mean streets of San Francisco, trying to find their home across the Golden Gate Bridge. But the road is blocked by a series of hazards, both man and beast.

Two losers from Milwaukee, Coop & Remer, invent a new game playing basketball, using baseball rules. When the game becomes a huge success, they, along with a billionaire’s help, form the Professional Baseketball League where everyone gets the same pay and no team can change cities. Theirs is the only team standing in the way of major rule changes that the owner of a rival team wants to institute.