Europe on the verge of social and economic change. A close up into the shaken vision of four couples, daily struggles, fights, kids, sex and passion. A movie about the politics of love. Le cinéma politique fait l’amour.

By coincidence rather then by design the swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact not only on the scientific world. THE SUBSTANCE – is an investigation into our troubled relation with LSD. Told from its beginnings until today.

Switzerland, 1955. The young orphan Max is sent as a foster child and contracted to work for the Bösiger family who lives on a farm. His foster parents treat him like a workhorse while their son seizes every opportunity to humiliate him. Playing the accordion is the one thing that is entirely his. But when the new teacher stands up for Max, it only makes a bad situation much worse. The only thing preserving his will to survive is his friendship with Berteli, who was also taken on to work at the farm. Max dreams of Argentina with her: a fantasy world, where allegedly even hayforks are made of silver.

The little witch is only 127 years old – too young for the annual coven of witches. Although she is not yet old enough to be a real witch she wants to become a really good one. This decision causes trouble inside her magic world.

After her mother decided that the eighteen-year-old mentally disabled Dora no longer has to take psychotherapeutic drugs, the young woman begins to blossom. The sedated teenager was never a problem for her surroundings – but new challenges arise when the pleasure-loving young woman discovers her sexuality. The family is threatened to fall apart.