When their plans for a nature trip go awry, Polly and boyfriend Seth decide to check into a motel. On their way, they’re carjacked and kidnapped by low-rent crooks Dennis and Lacey, who take the victims and their SUV to a nearby gas station. Along the way, they encounter an increasingly terrifying horde of parasites, and if any of them intend to survive, they’ll have to outsmart the deadly organisms.

Jake, the sole survivor of The Grudge 2 massacre, is tortured by chilling visions of Kayako and Toshio that have led to his hospitalization. Jake’s caretaker, Dr. Sullivan is determined to investigate his horrifying tales. She explores his Chicago home, finding another family on the brink of succumbing to the curse. It becomes clear that Jake’s terrifying stories are true, and a mysterious Japanese woman may be the only hope of banishing the spirits forever…unless her plan destroys them all.