Some college students manage to persuade the town’s big businessman, A. J. Arno, to donate a computer to their college. When the problem- student, Dexter Riley, tries to fix the computer, he gets an electric shock and his brain turns to a computer; now he remembers everything he reads. Unfortunately, he also remembers information which was in the computer’s memory, like Arno’s illegal businesses..

Dexter Riley is a science student at Medfield College who inadvertently invents a liquid capable of rendering objects and people invisible. Before Dexter and his friends, Debbie and Richard Schuyler, can even enjoy their spectacular discovery, corrupt businessman A.J. Arno plots to get his greedy hands on it. Slapstick hijinks ensue as Dexter and his pals try to thwart the evil Arno before he can use the invisibility spray to rob a bank.

Bob McGraw is in his 12th year of college, goofing his way through life. Bob, Irwing, Gonzer and Max are the four losers forced and bribed to represent their university in an intercollegiate raft race. Forced and bribed into this role, they make some friends, the lovely Heather Merriweather, but mostly enemies, among others a whole team of marines, and preppy IVY-leaguers determined to win.

On a flight transporting dangerous convicts, murderer Ryan Weaver manages to break free and cause complete chaos throughout the plane. As various people on board fall victim to Weaver, it is ultimately down to flight attendant Teri Halloran to keep the aircraft from crashing, with on-ground support from an air traffic controller. While Halloran struggles to pilot the plane, Weaver continues to terrorize the surviving members of the crew.