The seemingly random killings of an assassin puzzle her former lover, a wealthy Greek crime boss whose organization is jeopardized by his love for her, and the detective following her rising body count

On a flight from Los Angeles to Paris, a mad scientist on the run from the CIA is transporting a coffin containing the body of a colleague infected with a genetically modified virus. While the 747 crosses a violent thunderstorm, the instability of the aircraft allows the corpse to get out of its container.