After a heroic job of successfully landing his storm-damaged aircraft in a war zone, a fearless pilot finds himself between the agendas of multiple militias planning to take the plane and its passengers hostage.

A rare mutation has occurred within the vampire community – The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.