Grace Rhodes, who is studying to be a doctor, returns to her hometown as a strange illness is afflicting the local children. The symptoms include a high fever and spasms, but even weirder is what happens the next day: All those with the illness claim they are somebody else — then they begin murdering the grown-ups. After her sister undergoes the same sinister metamorphosis, Grace comes to believe there is some connection to an evil cult figure who may be returning from the grave.

Gabriel returns to try to destroy the human race he despises so much, with the help of a suicidal teen and the opposition of the angel Daniel.