A female doctor at a men’s clinic crosses paths with a male doctor at a women’s clinic. Sin-seol is a virgin female urologist. Her main job is to give medical treatment to men who have lost confidence in sex. Seong-ki is a male obstetrician who suffers from a traumatic memory. After failing to deliver a baby in a Cesarean operation, he becomes impotent even with the sexiest girls. When the two become neighbors, they conflict with each other on everything. One night Seong-ki finds a blind drunk Sin-seol on the street, and carries her home. When she accidentally touches his thing, strangely enough, IT responds. Can the competent urologist Sin-seol finally help him to get IT up?

Ji-wook is a cold-blooded detective who would brutally assault and stop at nothing to catch criminals. However, despite her perfectly masculine appearance, Ji-wook struggles with a secret desire to be a woman. At last, Ji-wook decides to transition. However, a gang Ji-wook brutally arrested by force plots revenge against him. While Ji-wook resigns and secretly dreams of transitioning into a woman, people close to her get caught up in a conspiracy and killed. When the one person he must protect, Jang-mi, also falls in danger, Ji-wook faces a crossroads in making his choice.