For high schooler Kei—and for at least forty-six others—immortality comes as the nastiest surprise ever. Sadly for Kei, such a feat doesn’t make him a superhero. In the eyes of both the general public and governments, he’s a rare specimen who needs to be hunted down and handed over to scientists to be experimented on for life—a demi-human who must die a thousand deaths for the benefit of humanity.

When he was a child, Murakami was friends with a girl he called Kuroneko. One day, while trying to prove the existence of aliens to Murakami, she is killed in an accident that he barely survives. Guilty of his role in the accident, Murokami decides to dedicate his life to proving that aliens exist. Then, one day, a new student with mysterious powers transfers into his class who not only looks a lot like Kuroneko, but is named Kuroha, Neko.

As a child Sakura Mamiya mysteriously disappeared in the woods behind her grandma’s home. She returned whole and healthy, but since then she has had the power to see ghosts. Now a teenager, she just wishes the ghosts would leave her alone! At school, the desk next to Sakura’s has been empty since the start of the school year, then one day her always-absent classmate shows up, and he’s far more than what he seems!

17 years ago, immortals first appeared on the battlefields of Africa. Later, rare, unknown new immortal lifeforms began appearing among humans, and they became known as “Ajin” (demi-humans). Just before summer vacation, a Japanese high school student is instantly killed in a traffic accident on his way home from school. However, he is revived, and a price is placed on his head. Thus begins a boy’s life on the run from all of humankind.

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The film’s story begins when Arata inadvertently touches “Hermes Apocrypha,” Lilith’s Grimoire. Suddenly, he is enveloped by a bright white light, and a girl appears before him. She calls herself Lilim, and treats both Arata and Lilith as her parents. At the same time she appears, something changes in the world. The forbidden Eternal Library awakens. In the Library is sealed the ultimate culmination of Alchemy, the White Demon Lord. The White Demon Lord plots to eliminate Arata and the Trinity Seven to usurp the position of Demon Lord. Bristling with untold power, the White Demon Lord attacks Arata, and triggers a desperate crisis where Arata and the Trinity Seven must save the world in this last battle.

In the distant technological future, civilization has reached its ultimate Net-based form. An “infection” in the past caused the automated systems to spiral out of order, resulting in a multi-leveled city structure that replicates itself infinitely in all directions. Now humanity has lost access to the city’s controls, and is hunted down and purged by the defense system known as the Safeguard. In a tiny corner of the city, a little enclave known as the Electro-Fishers is facing eventual extinction, trapped between the threat of the Safeguard and dwindling food supplies. A girl named Zuru goes on a journey to find food for her village, only to inadvertently cause doom when an observation tower senses her and summons a Safeguard pack to eliminate the threat. With her companions dead and all escape routes blocked, the only thing that can save her now is the sudden arrival of Killy the Wanderer, on his quest for the Net Terminal Genes, the key to restoring order to the world.

In the future, Utopia has finally been achieved thanks to medical nanotechnology and a powerful ethic of social welfare and mutual consideration. This perfect world isn’t that perfect though, and three young girls stand up to totalitarian kindness and super-medicine by attempting suicide via starvation. It doesn’t work, but one of the girls—Tuan Kirie—grows up to be a member of the World Health Organization. As a crisis threatens the harmony of the new world, Tuan rediscovers another member of her suicide pact, and together they must help save the planet…from itself.